In this informative segment, we delve into the topic of leaky gut, a condition characterized by increased intestinal permeability, where the tight junctions in the intestinal walls open inappropriately. This allows harmful particles such as microbial fragments and undigested proteins to enter the bloodstream, potentially triggering immune reactions, food sensitivities, and skin issues such as acne and eczema.
Understanding Zonulin, the protein that regulates these tight junctions, is crucial. Elevated levels of Zonulin can lead to these tight junctions remaining open too frequently, contributing to gut health issues.
We explore six powerful nutrients that can aid in repairing the intestinal barrier: Zinc L-Carnosine, Glutamine, Butyrate (Tributyrin), Collagen Peptides, and Retinol (Cod Liver Oil). These nutrients play a foundational role in supporting the cells lining the intestines and maintaining appropriate Zonulin regulation.
💡 For scientific references on this topic, consider the following studies:
📚 Mu Q, Kirby J, Reilly CM, Luo XM. Leaky Gut As a Danger Signal for Autoimmune Diseases. Front Immunol. 2017.
https://pubmed.ncbi.nlm.nih.gov/28588585/
📚 Fasano A. Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiol Rev. 2011.
https://pubmed.ncbi.nlm.nih.gov/21248165/
📚 Efthymakis K, Neri M. The role of Zinc L-Carnosine in the prevention and treatment of gastrointestinal mucosal disease in humans: a review. Clin Res Hepatol Gastroenterol. 2022.
https://pubmed.ncbi.nlm.nih.gov/35659631/
📚 Achamrah N, Déchelotte P, Coëffier M. Glutamine and the regulation of intestinal permeability: from bench to bedside. Curr Opin Clin Nutr Metab Care. 2017.
https://pubmed.ncbi.nlm.nih.gov/27749689/
📚 Hodgkinson K, El Abbar F, Dobranowski P, Manoogian J, Butcher J, Figeys D, Mack D, Stintzi A. Butyrate’s role in human health and the current progress towards its clinical application to treat gastrointestinal disease. Clin Nutr. 2023.
https://pubmed.ncbi.nlm.nih.gov/36502573/
📚 Chen Q, Chen O, Martins IM, Hou H, Zhao X, Blumberg JB, Li B. Collagen peptides ameliorate intestinal epithelial barrier dysfunction in immunostimulatory Caco-2 cell monolayers via enhancing tight junctions. Food Funct. 2017.
https://pubmed.ncbi.nlm.nih.gov/28174772/
📚 Louis P, Flint HJ. Formation of propionate and butyrate by the human colonic microbiota. Environ Microbiol. 2017.
https://pubmed.ncbi.nlm.nih.gov/27446020/
If you’re interested in enhancing your gut health, check out Ryan’s favorite products:
🌿 Zinc L-Carnosine: https://iherb.co/AhYjQb2c
🌿 Glutamine Powder: https://iherb.co/4gySe4hx
🌿 Tributyrin: https://iherb.co/YZFvJD7i
🌿 Collagen Peptides: https://iherb.co/3szdqr7K
🌿 Cod Liver Oil (Vitamin A): https://iherb.co/WEp3DEv4
By Ryan Taylor (Natural Remedies)