The video delves into the intricacies of iron physiology, exploring its various facets from dietary sources to absorption and regulation in the body.
Firstly, we differentiate between heme and non-heme iron, which are crucial dietary sources. Heme iron is found in animal products and is generally absorbed more efficiently than non-heme iron, which comes from plant-based sources. Understanding the difference aids in optimizing dietary choices.
Iron absorption occurs in the gut, where an acidic environment is essential for the functioning of the DMT1 transporter, which facilitates the uptake of iron. After absorption, iron is stored safely in the body in the form of ferritin and transported by transferrin, ensuring that it reaches cells where it is needed.
The regulation of iron levels is a critical process, primarily managed by hepcidin and ferroportin. Hepcidin controls the amount of iron that enters the bloodstream, while ferroportin helps transport iron out of cells. This delicate balance is vital because while iron is essential for various bodily functions, excess iron can be harmful when left ‘free’ in the body.
Moreover, the video discusses factors that influence iron absorption, including substances like vitamin C, which enhances absorption, and phytates, tea, coffee, calcium, and PPIs, which can inhibit it. This knowledge is valuable for people looking to optimize their iron intake and overall health.
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By Dr Matt & Dr Mike